Tag Archives: 23andme

GEEEEEENES

Hey so my 23andMe ancestry composition has updated a bit with their new algorithms. Check it:

  • The “French & German” went waaay up from 28.7% to 43.9%
  • The “British & Irish” went down from 4.2% to 0.1%
  • The “Native American” went up from 8.8% to 9.1%
  • The miniscule bit of “Japanese & Korean” is new
  • The “Sub-Saharan African” category went down from 2.2% to 1.8%, but the individual regions got a bit more specific I think.

I am very German, haha.

Coolio!

Ancestry

So remember a few weeks ago when I said that Nate and I finally completed and mailed our Ancestry.com thingies? Well, I got my results today!

Since I did the 23andMe version of this like eight years ago, I had a good idea what to expect with my results. However, Ancestry seems to have a bit more detail/specifics as far as some populations go (especially in Europe).

I know 23andMe didn’t specifically pick out the Welsh, Swedish, or Basque; I think they just got lumped in with larger regions. And I don’t think my regions in Africa were quite as specific.

(I should just check. Lemme check.)

OKAY NOPE I LIED, the African regions are split more precisely on 23andMe and the European regions are split more precisely on Ancestry.

Anyway, all of the non-European bits come from my dad’s side. My mom is 100% European.

Also, I’m currently reading Exodus and learning a lot about the Jewish people and Jewish history in general, so I’m super curious about that itty bitty little 2% European Jewish background and where that’s actually coming from.

Coolio!

GEEEEEEEEENES

Hey, nerds!

I’ve mentioned my 23andMe results on here a few times now, and since I first got the testing done in 2012, they’ve refined some of their ancestry algorithms, causing some small changes to my results. Here’s what’s changed per region:

European: still 87.6%

  • French and German went from 15.4% to 28.7%, with strongest evidence of ancestry in Baden-Württemberg, Bavaria (both Germany), and Friesland (Netherlands)
  • British and Irish went from 13.2% to 4.2%
  • Ashkenazi Jewish went from 0.7% to 0.5%

East Asian and Native American: went from 9.2% to 9.0%

  • Native American went from 8.3% to 8.8%, with strongest evidence of ancestry in Sonora (Mexico)

Sub-Saharan African: went from 2.1% to 2.2%

So that’s kinda cool.

I was actually thinking of getting my mom and myself a kit from Ancestry.com, since that’s what my dad used for his ancestry a while back and then we could all compare each other based on one company’s results. It’d also be curious to see how different Ancestry.com would be from 23andMe as far as the results go.

Anyway.

Interesting…

So here’s something interesting.

I was looking at my old 23andMe results that I got back in like 2012, ‘cause I wanted to show them to Nate. Back when I had first gotten the results back, I was more interested in the medical results (things I have more of a risk of getting, things I am low risk for, etc.). But today, I decided to look in more detail at the Ancestry Composition information. Here’s what I’ve got for my composition:

kjlk

First off, I thought I was basically 100% European. Which is apparently not the case. I have no idea where that relatively large (in my opinion—remember I thought I was like 100% European) Native American percentage is coming from. Or that tiny bit of West African. Like…have you seen my family?

Also, something I didn’t know: Ashkenazi is a Jewish ethnic division, mainly from Germany, so that’s cool.

So I am mainly European, but not as European as I thought I was.

Random stuff from 23andMe ’cause I’m bored.

I was messing around on 23andMe this afternoon. Here are two little graphics showing the distribution of hair color and eye color for the 23andMe community. The ones with the little green blat next to them were my choices.

In This Blog: I Unzip My Genes

On February 1st I sent a tube of my spit through the mail with the goal to have my genetics explored via the services offered by 23andMe. Today I got an email saying that my results were complete! And now we shall commence with examining the results.

23andMe, for those of you who don’t know, is a DNA testing service that provides customers an insight into their DNA. Pay for a kit, receive it, spit into the special tube, and send it back and within 6 – 8 weeks, you’ll receive an online report detailing 118 disease risks, 55 traits, 20 drug responses, and 44 carrier statuses.

Knowing a bit about the general health characteristics of my family, I had a few conjectures regarding what I thought the results would show in terms of disease risk:

What I thought would be higher risk than average – diabetes (it’s on both sides of my family), Alzheimer’s (also on both sides of my family), kidney stones and gout (my dad’s had both of these), and possibly high blood pressure (my dad has this, my mom’s had it intermittently)

What I thought would be lower risk than average – the cancers (there’s not a lot of any specific type or much cancer at all in my family) and coronary heart disease (NONE of this in the family).

I also had some guesses as to what some of my trait results would be:

I’m guessing my bitter taste perception is poor due to my extreme liking of broccoli and Brussels sprouts and the like.

If my anosmia is genetic, I’m guessing I’ll lack the genetic component responsible for detecting isovaleric acid, a sweaty-type smell.

I’m also guessing that I’ll show up as sensitive to at least a few of the drugs they examine, as I’ve had major reactions to pretty much every drug I’ve ever been on.

So those were my conjectures. Want to see what my DNA really says? Let’s break it down by category.

Disease Risk
Pretty much every single one of my major* results surprised me. I have almost double the average risk for—wait for it—gallstones. I also have elevated risk for macular degeneration, glaucoma, restless leg syndrome, and primary biliary cirrhosis.

Even more interesting to me are my decreased risk diseases. Alzheimer’s and diabetes, the two major issues in my family? Genetically, I’m at decreased risk for both of them (I’m at nearly half the average genetic risk for Alzheimer’s). The two ailments of my father, gout and kidney stones, are two other diseases for which I’m at decreased risk.  I’m also at low risk for rheumatoid arthritisceliac disease, lupus (sorry, House), and endometriosis.

A few things for which I  have average risk: obesity, coronary heart disease (interesting…), chronic kidney disease, atrial fibrillation.

Traits
Now we come to what, in my opinion, was the really fun stuff to look at. Here are a few that surprised me/were pretty interesting.

As I expected, I have “about an 80% chance of not being able to taste certain bitter flavors.” This makes me “taste blind” to the bitterness of foods of the cabbage family.

I am “likely tolerant” of lactose, which makes sense. I’ve never had a problem with dairy, even when I used to drink at least a glass of milk a day.

According to one marker for intelligence, my IQ performance should be about 3 points higher than average.

I am a “likely sprinter,” which means that I’ve got one gene that is turned on in a type of muscle fiber used for power-based sports (a fast-twitch muscle fiber). I’ve never worked out with sprints (I’ve always run long distances)…perhaps I should give it a try.

I AM sensitive to isovaleric acid, the sweaty-type odor. Perhaps my anosmia is physical/structural and not genetic? Obviously this one marker isn’t responsible for all olfaction, but still.

I have typical sensitivity to pain.

I am at slightly higher odds of developing tuberculosis if I were to be exposed to it.

Drug Response
DRUGGGS! This whole category surprised me. Of the 20 drug responses they test for, the only drug for which I showed increased sensitivity to was Warfarin, a blood thinner.

What am I missing…oh yeah, the carrier statuses. Of the 44 tested for, I don’t carry any of the diseases/deficiencies.

So what does all this mean, then? It probably won’t be bad genes that kill me, so I’ll either have to slog through to old age or dive in front of a bus.

Woo!

*23andMe denotes “elevated risk” and “reduced risk” as cases where an individual’s risk due to genetics is 20% or more above average for the disease or 20% or more below the average for the disease, respectively.

CLICK-CLICK-BOOM-BOOM-SNAP-POP-WATER-WEDGE

So 23andMe has a bunch of little surveys you can opt to take. Once you answer them you’re shown the stats for each question based on the people who have already taken the surveys.

Three interesting tidbits about our fellow humans. My answers are starred green.

IN OTHER NEWS! New plan for completing my walking distance goal this year: because I finally am working a full-time job, I can no longer walk my 10 (or 12 or 15 or 22) miles per day, ‘cause that obviously takes a long time to do. So I decided to count running distance toward my final goal. To reach my 2,500 I’ll need to either:

a) run 5 miles four days a week (one day off during the week) and two 15-mile walks on the weekends, or

b) run 10k (approximately 6.2 miles) four days a week and two 12- or 13-mile walks on the weekends.

I’ll probably do b) while the days are still relatively short, but once it’s light longer I’ll probably switch to a).

A Random $1,900 Appears!

As I said on Facebook, random large sums of money appearing in one’s checking account are awesome, except when one does not know the origin of said random large sums.

Yeah, I decided to randomly check my RBC account up in Canada (I’d left exactly $2.90 in there just to keep the account open until tax time) and discovered that that amount had been supplemented an additional $1,900 or so. The record says the money came from UWO, but that’s all the more info I can get.

It was deposited at the end of November; I think I’ll wait until the first of the year to see if another deposit is made at the end of this month and if so, I guess I’ll email somebody there and ask what’s going on. It might all be an error, who knows.

But that would be pretty freaking sweet if it weren’t.

There are some good paying jobs down here that I qualify for, but until I’m hired somewhere, money = nonexistent.

And I want that DNA test thingy; it was supposed to be my present to myself for finishing my Master’s but I never ordered it ‘cause shipping to Canada was like $50 extra.

So we’ll see!

DNA? Please!

Check this out: https://www.23andme.com/

I’m totally considering getting this done as my graduation present to myself.
Assuming, you know, I pass my thesis defense.

Reasons:
– Because it would be awesome
– Because they test odor detection
– And tardive dyskinesia
– AND gout, which my father has

It looks pretty legit, and things like this have always interested me.

$99 seems reasonable enough, too, especially as a reward for two years of hell.